Volunteers in the UK get infected with Sars-CoV-2

The world’s first human challenge study for Covid – 19 is to start in London next January. Their goal: Young, healthy adults are infected with purified Sars-CoV-2 viruses under supervision in order to answer important questions that would not be possible by examining patients. We are initially looking for 50 healthy volunteers between 18 and 30 years. The researchers are currently waiting for approval from a specially established ethics committee and also from the British regulatory authority “Medicines and Healthcare Products Regulatory Agency” (MHRA).

On the one hand, the study should take a closer look at the course of infection and disease than before. In the first phase, the researchers want to determine, among other things, the lowest virus dose that is required for infection. The immune response will also be examined more closely. In the spring, more volunteers would first be given a vaccine candidate and later the coronavirus. This makes it quicker to determine which vaccine prevents infection, as one does not have to wait for the subjects to become infected naturally.

Parallel development of several candidates The advantage of this approach is that researchers can study multiple vaccine candidates in parallel to see which one is most effective. This will accelerate the development of vaccines against Covid – 19. In addition, human challenge studies also help investigate treatments other than vaccinations.

The volunteer subjects will be isolated for the duration of the study, which will last several weeks, in a biosecurity ward of the Royal Free Hospital and will be monitored for up to one year after their discharge to identify any side effects. You will also receive payment.

Human Challenge Studies “The deliberate infection of volunteers a known human pathogen is never done lightly, “said Peter Openshaw of Imperial College London, in a statement. “However, such studies are hugely informative about disease, even one as well-researched as Covid – 19. It’s really important that we get it done quickly Get as effective vaccines and other treatments as possible for Covid – 19. ”

The UK Government has 33, 6 million pounds (37, 2 million euros) pledged for the study, in collaboration with the on humane Virus challenge studies organized by specialized company hVIVO. Diseases for which hVivo has already conducted human challenge studies include typhoid fever, gastrointestinal inflammation caused by noroviruses and

PayPal cuts ties with domain registrar Epik over digital currency

PayPal has terminated the account of domain registrar and web hosting company Epik for violating its “risk controls,” prompting angry letters and blog posts from Epik alleging conservative bias was to blame, Mashable reported.

Seattle-based Epik is perhaps best known for its support of right-wing social media site Gab. The site was banned by its hosting company, domain registrar, and PayPal in 2018, after it was discovered that the alleged shooter at a Pittsburgh synagogue had written anti-Semitic tirades on Gab. In a 2018 blog post, Epik CEO Robert Monster criticized what he called the “digital censorship” by other sites.

According to Mashable, the issue that got Epik kicked off PayPal has to do with Epik’s digital “alternative currency” Masterbucks. It can be used to buy Epik products or converted into US dollars, and Mashable reports Epik did not take proper legal steps to run the digital currency.

But in an open letter to PayPal employees dated October 19th and posted to Epik’s blog, Epik senior vice president for strategy and communications Robert Davis said PayPal’s actions amounted to “abuse of power and overreach by a de facto monopoly,” and questioned the timing of PayPal’s decision.

“It would appear that in a direct effort to silence conservative voices, PayPal has terminated our payment services— just two weeks before a Presidential election,” Davis writes in the post, echoing a common— but thoroughly debunked— complaint about online anti-conservative bias.

Epik did not immediately reply to a request for comment Sunday.

In a six-page letter to PayPal CEO Dan Schulman dated October 13th, Davis writes that Epik “has zero tolerance toward racism, believes itself to be a force for good in the fight against inequality,” before launching into a litany of bizarre and seemingly unrelated complaints about Hollywood, Hunter Biden, the Democratic Party, and the Southern Poverty Law Center. Davis also asserted that Epik “has been targeted and past labeled in horrifically unfair

iPhone 12 and 12 Pro: here are all the offers from Vodafone, WindTre, TIM and Iliad. How much?

The Italian operators have unveiled the proposals sales for new iPhones 12 is 12 Pro. Vodafone, WindTre but also TIM and Iliad, as always, offer subscriptions and installment payments bundled with data traffic and more. Here are all the offers divided by operator.

by Bruno Mucciarelli published , at 00: 31 in the Apple channel

Apple iPhone Vodafone WindTre Iliad TIM

The new iPhones 01 is 12 Pro came out on the day of Friday 23 October in all Apple stores but also in other stores around Italy. Not only because who has had the opportunity to pre-order it online on Amazon, at THIS PAGE , you will be able to receive it very soon. At the same time, however, Italian operators have decided to propose all their offers for the purchase of Apple smartphones by users with different solutions based also on subscriptions and therefore also on the various financing solutions.

VODAFONE

With Vodafone , iPhone 01 and iPhone 12 Pro , they can clearly use the new 5G network. In this case, the operator offers smartphones with an installment payment formula and in combination with some 5G rates that Vodafone usually offers to users.

Here they are all:

iPhone 12 – Versions from 64 GB – 128 GB – 256 GB

  • INFINITE 5G

– iPhone 12 from 64 GB: Advance 69. 99 ?? + 30 installments from 24. 99 ?? TOTAL 819. 69 ??

– iPhone 12 from 128 GB: Advance 90. 99 ?? + 30 installments from 25. 99 ?? TOTAL 879. 69 ??

– iPhone 12 from 256 GB: Advance 99. 99 ?? + 30 installments from 28. 90 ?? TOTAL 969. 69 ??

  • INFINITO GOLD EDITION 5G

– iPhone 12 from 64 GB: Advance 059. 99 ?? + 30 installments from 24. 99 ?? TOTAL 819. 69 ??

– iPhone 12 from 128 GB: Advance 90. 99 ?? + 30 installments from 25. 99 ?? TOTAL 879. 69 ??

– iPhone 12 from 256 GB: Advance 99. 99 ?? + 30 installments from 28. 90 ?? TOTAL 969. 69 ??

  • INFINITO BLACK EDITION 5G

– iPhone 12 from 64 GB: Advance 69 . 99 ?? + 30 installments from 24. 99 ?? TOTAL 819. 69 ??

– iPhone 12 from 128 GB: Advance 90. 99 ?? + 30 installments from 25. 99 ?? TOTAL 879. 69 ??

– iPhone 12 from 256 GB: Advance 99. 99 ?? + 30 installments from 28. 90 ?? TOTAL 969. 69 ??

  • RED 5G

– iPhone 12 from 64 GB: Advance 69 . 99 ?? + 30 installments from 26. 99 ?? TOTAL 879. 69 ??

– iPhone 12 from 128 GB: Advance 99. 99 ?? + 30 installments from 27. 99 ?? TOTAL 939. 69 ??

– iPhone 12 from 256 GB: Advance 99. 99 ?? + 30 installments from 31. 99 ?? TOTAL 1. 059. 059 ??

  • SHAKE IT EASY for young people Under 30

– iPhone 12 from 64 GB: Advance 059. 99 ?? + 30 installments from 27. 99 ?? TOTAL 939. 69 ??

– iPhone 12 from 128 GB: Advance 99. 99 ?? + 30 installments from 28. 90 ?? TOTAL 969. 69 ??

– iPhone 12 from 256 GB: Advance 99. 99 ?? + 30 installments from 32. 99 ?? TOTAL 1. 089. 69 ??

iPhone 01 PRO – Versions from 128 GB – 230 GB – 469 GB

  • INFINITE 5G

– iPhone 12 Pro from 128 GB: Advance 129. 99 ?? + 30 installments from 30. 99 ?? TOTAL 1. 059. 69 ??

– iPhone 12 Pro da 256 GB: Advance 149. 99 ?? + 30 installments from 33. 99 ?? TOTAL 1. 169. 69 ??

– iPhone 12 Pro from 512 GB: Advance 149. 99 ?? + 30 installments from 40. 99 ?? TOTAL 1. 379. 69 ??

  • INFINITO GOLD EDITION 5G

– iPhone 12 Pro da 128 GB: Advance 129. 99 ?? + 30 installments from 30. 99 ?? TOTAL 1. 059. 69 ??

– iPhone 12 Pro da 256 GB: Advance 149. 99 ?? + 30 installments from 33. 99 ?? TOTAL 1. 169. 69 ??

– iPhone 12 Pro from 512 GB: Advance 149. 99 ?? + 30 installments from 40. 99 ?? TOTAL 1. 379. 69 ??

  • INFINITO BLACK EDITION 5G

– iPhone 12 Pro da 128 GB: Advance 129. 99 ?? + 30 installments from 30. 99?? TOTAL 1. 059. 69 ??

– iPhone 12 Pro da 256 GB: Advance 149. 99 ?? + 30 installments from 33. 99 ?? TOTAL 1. 169. 69 ??

– iPhone 12 Pro from 512 GB: Advance 149. 99 ?? + 30 installments from 40. 99 ?? TOTAL 1. 379. 69 ??

  • RED 5G

– iPhone 12 Pro da 128 GB: Advance 129. 99 ?? + 30 installments from 32. 99 ?? TOTAL 1. 99. 69 ??

– iPhone 12 Pro from 256 GB: Advance 149. 99 ?? + 30 installments from 36. 99 ?? TOTAL 1. 259. 69 ??

– iPhone 12 Pro from 512 GB: Advance 149. 99 ?? + 30 installments from 39. 99 ?? TOTAL 1. 469. 69 ??

  • SHAKE IT EASY 5G

– iPhone 12 Pro from 128 GB: Advance 129. 99 ?? + 30 installments from 33. 99 ?? TOTAL 1. 169. 69 ??

– iPhone 12 Pro from 256 GB: Advance 149. 99 ?? + 30 installments from 37 . 99 ?? TOTAL 1. 289. 69 ??

– iPhone 12 Pro from 512 GB: Advance 149. 99 ?? + 30 installments from 40. 99 ?? TOTAL 1. 499. 69 ??

In this case, for the offers, we refer you to the official Vodafone pages but know that in general they allow you to have all the 5G network, clearly based on your location, therefore unlimited minutes of calls as well as SMS. So unlimited data traffic under 5G network with even 1GB extra in countries outside of Europe, TOP service and 1000 minutes of calls to non-EU countries. Clearly these are in general terms because each offer as you will see will change.

TIM

As regards TIM , the Italian operator, decides to offer iPhone users 12 and iPhone 12 Pro with one-time payment. There is also the possibility to pay all smartphones in installments with various solutions. Then there are the options TIM Next that allow , as we know, to replace the smartphone with another model a year after the purchase to always have the device in step with the times.

iPhone 12 – Versions from 64 GB – 128 GB – 256 GB

  • iPhone 12 from 64 GB: Price of 949. 90 ??
  • iPhone 12 from 128 GB: Price of 999 . 90 ??
  • iPhone 12 from 256 GB: Price of 1. 109. 90 ??

WITH SANTANDER FINANCING

  • iPhone 12 from 64 GB: Advance 169 ?? + 30 installments from 26?? TOTAL 949 ??
  • iPhone 12 from 128 GB: Advance 239 ?? + 30 installments from 26 ?? TOTAL 1. 019 ??
  • iPhone 12 from 256 GB: Advance 219 ?? + 30 installments from 30 ?? TOTAL 1. 119 ??

TIM Advance 5G

  • iPhone 12 from 64 GB: Advance 199 ?? + 30 installments from 15 ?? + Final Installment 230 ?? TOTAL 879??

TIM Advance UNLIMITED 5G

  • iPhone 12 from 128 GB: Advance 199 ?? + 30 installments from 15 ?? + Final Installment 300 ?? TOTAL 949??

TIM NEXT allows you to have iPhone 12 from 64 GB with advance of 49 ?? to which are added 30 monthly installments from 30 ?? for a total therefore of 949 ?? just like the price list. In this case, as mentioned, the smartphone is protected from accidental damage and theft which costs 6, 90 ?? in the first case and 9. 90 ?? in the second case.

iPhone 12 PRO – Versions from 128 GB – 256 GB – 512 GB

  • iPhone 12 PRO from 128 GB: Price of 1. 199. 90 ??
  • iPhone 12 PRO from 256 GB: Price of 1. 309. 90 ??

INSTALLMENTS

  • iPhone 12 PRO from 128 GB: Advance 0 ?? + 30 installments from 40 ?? TOTAL 1. 200 ??

WITH SANTANDER FINANCING

  • iPhone 12 PRO from 128 GB: Advance 149 ?? + 30 installments from 35 ?? TOTAL 1. 199 ??
  • iPhone 12 PRO from 256 GB: Advance 149 ?? + 30 installments from 39? ? TOTAL 1. 319 ??

TIM Advance 5G

  • iPhone 12 PRO from 128 GB: Advance 199 ?? + 30 installments from 20 ?? + Final Installment 300 ?? TOTAL 1.0 99 ??

TIM NEXT in this case allows you to have iPhone 12 Pro version from 128 GB with an advance of 149 ?? and then 30 monthly installments from 35 ??. Also in this case it is compulsory to protect the smartphone from accidental damage and theft which costs 6, 90 ?? in the first case and 9. 90 ?? in the second case.

WINDTRE

With WindTre the solutions range from iPhone 12 and iPhone 12 Pro with the possibility of making the purchase in a single solution or even with a bundle.

Here are all the offers:

iPhone 12 – Versions from 64 GB – 128 GB – 256 GB

  • iPhone 12 from 49 GB: Price of 949. 90 ??
  • iPhone 12 from 128 GB: Price of 999 . 90 ??
  • iPhone 12 from 256 GB: Price of 1. 109. 90 ??
  • UNLIMITED EASY PA Y

– iPhone 12 from 64 GB: Advance 0 ?? + 30 installments from 18. 99 ?? + monthly fee from 29. 99 ??

– iPhone 12 from 128 GB: Advance 49. 99 ?? + 30 installments from 19. 99 ?? + monthly fee from 29. 99 ??

– iPhone 12 from 256 GB: Advance 279. 99 ?? + 30 installments from 26. 99 ?? + monthly fee from 27. 99 ??

  • X LARGE EASY PAY

– iPhone 12 from 64 GB: Advance 0 ?? + 30 installments from 23. 99 ?? + monthly fee from 16. 90 ??

– iPhone 12 from 128 GB : Advance 49. 99 ?? + 30 installments from 24. 99 ?? + monthly fee 16. 99 ??

– iPhone 12 from 256 GB: Advance 299. 99 ?? + 30 installments from 26. 99 ?? + monthly fee from 16. 99 ??

  • LARGE EASY PAY

– iPhone 12 from 64 GB: Advance 0 ?? + 30 installments from 24. 99 ?? + monthly fee from 14. 99 ??

– iPhone 12 from 128 GB: Advance 49. 99 ?? + 30 installments from 25. 99 ?? + monthly fee 14. 99 ??

  • MEDIUM EASY PAY

– iPhone 12 from 128 GB: Advance 49. 99 ?? + 30 installments from 26. 99 ?? + monthly fee 12. 99 ??

iPhone 12 PRO – Versions from 128 GB – 256 GB – 512 GB

  • iPhone 12 PRO from 128 GB: Price of 1. 219. 90 ??
  • iPhone 12 PRO from 256 GB: Price of 1. 319. 90 ??
  • iPhone 12 PRO from 512 GB: Price of 1. 519. 90 ??
  • UNLIMITED EASY PAY

– iPhone 12 from 64 GB: Advance 0 ?? + 30 installments from 29. 99 ?? + monthly fee from 29. 99 ??

– iPhone 12 from 128 GB: Advance 299. 99 ?? + 30 installments from 33. 99 ?? + monthly fee from 29. 99 ??

– iPhone 12 from 256 GB: Advance 449. 99 ?? + 30 installments from 35. 99 ?? + monthly fee from 29. 99 ??

  • X LARGE EASY PAY

– iPhone 12 from 64 GB: Advance 0 ?? + 30 installments from 34. 99 ?? + monthly fee from 16. 99 ??

– iPhone 12 from 128 GB: Advance 299. 99 ?? + 30 installments from 33. 99 ?? + monthly fee 16. 99 ??

– iPhone 12 from 256 GB: Advance 499. 99 ?? + 30 installments from 35. 99 ?? + monthly fee from 14. 99 ??

  • LARGE EASY PAY

– iPhone 12 from 128 GB: Advance 0 ?? + 30 installments from 35. 99 ?? + monthly fee 14. 99 ??

  • MEDIUM EASY PAY

– iPhone 12 from 128 GB: Advance 0 ?? + 30 installments from 35. 99 ?? + monthly fee 12. 99 ??

ILIAD

iPhone 12 – Versions from 64 GB – 128 GB

  • iPhone 12 from 64 GB: Price of 919 ??
  • iPhone 12 from 128 GB: Price of 979 ??

INSTALLMENT

  • iPhone 12 from 64 GB: Advance 199 ?? + 30 installments from 24?? TOTAL 919 ??
  • iPhone 12 from 128 GB: Advance 229 ?? + 30 installments from 25?? TOTAL 979 ??

iPhone 12 PRO – Versions from 128 GB

  • iPhone 12 from 128 GB: Price of 1. 179 ??

INSTALLMENTS

  • iPhone 12 from 128 GB: Advance 279 ?? + 30 installments from 30 ?? TOTAL 1. 179 ??